An immune response study of oakmoss absolute and its constituents atranol and chloroatranol

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An immune response study of oakmoss absolute and its constituents atranol and chloroatranol. / Bonefeld, Charlotte Menné; Nielsen, Morten Milek; Gimenéz-Arnau, Elena; Lang, Matthieu; Vennegaard, Marie Torp; Geisler, Carsten; Johansen, Jeanne Duus; Lepoittevin, Jean-Pierre.

In: Contact Dermatitis, Vol. 70, No. 5, 2014, p. 282-290.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bonefeld, CM, Nielsen, MM, Gimenéz-Arnau, E, Lang, M, Vennegaard, MT, Geisler, C, Johansen, JD & Lepoittevin, J-P 2014, 'An immune response study of oakmoss absolute and its constituents atranol and chloroatranol', Contact Dermatitis, vol. 70, no. 5, pp. 282-290. https://doi.org/10.1111/cod.12177

APA

Bonefeld, C. M., Nielsen, M. M., Gimenéz-Arnau, E., Lang, M., Vennegaard, M. T., Geisler, C., Johansen, J. D., & Lepoittevin, J-P. (2014). An immune response study of oakmoss absolute and its constituents atranol and chloroatranol. Contact Dermatitis, 70(5), 282-290. https://doi.org/10.1111/cod.12177

Vancouver

Bonefeld CM, Nielsen MM, Gimenéz-Arnau E, Lang M, Vennegaard MT, Geisler C et al. An immune response study of oakmoss absolute and its constituents atranol and chloroatranol. Contact Dermatitis. 2014;70(5):282-290. https://doi.org/10.1111/cod.12177

Author

Bonefeld, Charlotte Menné ; Nielsen, Morten Milek ; Gimenéz-Arnau, Elena ; Lang, Matthieu ; Vennegaard, Marie Torp ; Geisler, Carsten ; Johansen, Jeanne Duus ; Lepoittevin, Jean-Pierre. / An immune response study of oakmoss absolute and its constituents atranol and chloroatranol. In: Contact Dermatitis. 2014 ; Vol. 70, No. 5. pp. 282-290.

Bibtex

@article{0103d30d62f44bb883c5d605c10ebbb5,
title = "An immune response study of oakmoss absolute and its constituents atranol and chloroatranol",
abstract = "BACKGROUND: Atranol and chloroatranol are the main allergens of oakmoss absolute. However, the immune responses induced by these substances are poorly characterized.OBJECTIVES: To characterize immune responses induced by atranol, chloroatranol and oakmoss absolute in mice.METHODS: Mice were sensitized and challenged with various concentrations of atranol, chloroatranol, and oakmoss absolute. The immune responses were analysed as B cell infiltration, T cell proliferation in the draining lymph nodes, and expression of interleukin (IL)-18, IL-1β and tumour necrosis factor-α in skin. The cytotoxicity of atranol and chloroatranol against keratinocytes was determined.RESULTS: Sensitization experiments showed that atranol, chloroatranol and oakmoss induced sensitization when applied in high concentrations. Challenge experiments showed that even low concentrations of atranol and chloroatranol induced sensitization. In parallel, atranol and chloroatranol elicited challenge reactions following sensitization with oakmoss. The magnitude of the immune response to the three allergens increased in the following order: atranol, chloroatranol, and oakmoss. The expression of proinflammatory cytokines was induced by chloroatranol and oakmoss, but not by atranol. Chloroatranol was found to be more cytotoxic than atranol against keratinocytes.CONCLUSIONS: Atranol and chloroatranol can elicit both sensitization and challenge reactions, but the mixture of allergens in oakmoss absolute is more potent than atranol and chloroatranol alone.",
keywords = "Animals, Antigens, CD19, B-Lymphocytes, Benzaldehydes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Line, Cell Proliferation, Dermatitis, Allergic Contact, Interleukin-18, Interleukin-1beta, Keratinocytes, Mice, Mice, Inbred CBA, Patch Tests, Resins, Plant, Terpenes, Tumor Necrosis Factor-alpha",
author = "Bonefeld, {Charlotte Menn{\'e}} and Nielsen, {Morten Milek} and Elena Gimen{\'e}z-Arnau and Matthieu Lang and Vennegaard, {Marie Torp} and Carsten Geisler and Johansen, {Jeanne Duus} and Jean-Pierre Lepoittevin",
note = "{\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2014",
doi = "10.1111/cod.12177",
language = "English",
volume = "70",
pages = "282--290",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - An immune response study of oakmoss absolute and its constituents atranol and chloroatranol

AU - Bonefeld, Charlotte Menné

AU - Nielsen, Morten Milek

AU - Gimenéz-Arnau, Elena

AU - Lang, Matthieu

AU - Vennegaard, Marie Torp

AU - Geisler, Carsten

AU - Johansen, Jeanne Duus

AU - Lepoittevin, Jean-Pierre

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Atranol and chloroatranol are the main allergens of oakmoss absolute. However, the immune responses induced by these substances are poorly characterized.OBJECTIVES: To characterize immune responses induced by atranol, chloroatranol and oakmoss absolute in mice.METHODS: Mice were sensitized and challenged with various concentrations of atranol, chloroatranol, and oakmoss absolute. The immune responses were analysed as B cell infiltration, T cell proliferation in the draining lymph nodes, and expression of interleukin (IL)-18, IL-1β and tumour necrosis factor-α in skin. The cytotoxicity of atranol and chloroatranol against keratinocytes was determined.RESULTS: Sensitization experiments showed that atranol, chloroatranol and oakmoss induced sensitization when applied in high concentrations. Challenge experiments showed that even low concentrations of atranol and chloroatranol induced sensitization. In parallel, atranol and chloroatranol elicited challenge reactions following sensitization with oakmoss. The magnitude of the immune response to the three allergens increased in the following order: atranol, chloroatranol, and oakmoss. The expression of proinflammatory cytokines was induced by chloroatranol and oakmoss, but not by atranol. Chloroatranol was found to be more cytotoxic than atranol against keratinocytes.CONCLUSIONS: Atranol and chloroatranol can elicit both sensitization and challenge reactions, but the mixture of allergens in oakmoss absolute is more potent than atranol and chloroatranol alone.

AB - BACKGROUND: Atranol and chloroatranol are the main allergens of oakmoss absolute. However, the immune responses induced by these substances are poorly characterized.OBJECTIVES: To characterize immune responses induced by atranol, chloroatranol and oakmoss absolute in mice.METHODS: Mice were sensitized and challenged with various concentrations of atranol, chloroatranol, and oakmoss absolute. The immune responses were analysed as B cell infiltration, T cell proliferation in the draining lymph nodes, and expression of interleukin (IL)-18, IL-1β and tumour necrosis factor-α in skin. The cytotoxicity of atranol and chloroatranol against keratinocytes was determined.RESULTS: Sensitization experiments showed that atranol, chloroatranol and oakmoss induced sensitization when applied in high concentrations. Challenge experiments showed that even low concentrations of atranol and chloroatranol induced sensitization. In parallel, atranol and chloroatranol elicited challenge reactions following sensitization with oakmoss. The magnitude of the immune response to the three allergens increased in the following order: atranol, chloroatranol, and oakmoss. The expression of proinflammatory cytokines was induced by chloroatranol and oakmoss, but not by atranol. Chloroatranol was found to be more cytotoxic than atranol against keratinocytes.CONCLUSIONS: Atranol and chloroatranol can elicit both sensitization and challenge reactions, but the mixture of allergens in oakmoss absolute is more potent than atranol and chloroatranol alone.

KW - Animals

KW - Antigens, CD19

KW - B-Lymphocytes

KW - Benzaldehydes

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Cell Line

KW - Cell Proliferation

KW - Dermatitis, Allergic Contact

KW - Interleukin-18

KW - Interleukin-1beta

KW - Keratinocytes

KW - Mice

KW - Mice, Inbred CBA

KW - Patch Tests

KW - Resins, Plant

KW - Terpenes

KW - Tumor Necrosis Factor-alpha

U2 - 10.1111/cod.12177

DO - 10.1111/cod.12177

M3 - Journal article

C2 - 24460794

VL - 70

SP - 282

EP - 290

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 5

ER -

ID: 135491165