Activated human CD4 T cells express transporters for both cysteine and cystine

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activated human CD4 T cells express transporters for both cysteine and cystine. / Levring, Trine Bøegh; Hansen, Ann Kathrine; Nielsen, Bodil Lisbeth; Kongsbak, Martin; von Essen, Marina Rode; Woetmann, Anders; Odum, Niels; Bonefeld, Charlotte Menné; Geisler, Carsten.

In: Scientific Reports, Vol. 2, 266, 14.02.2012.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Levring, TB, Hansen, AK, Nielsen, BL, Kongsbak, M, von Essen, MR, Woetmann, A, Odum, N, Bonefeld, CM & Geisler, C 2012, 'Activated human CD4 T cells express transporters for both cysteine and cystine', Scientific Reports, vol. 2, 266. https://doi.org/10.1038/srep00266

APA

Levring, T. B., Hansen, A. K., Nielsen, B. L., Kongsbak, M., von Essen, M. R., Woetmann, A., Odum, N., Bonefeld, C. M., & Geisler, C. (2012). Activated human CD4 T cells express transporters for both cysteine and cystine. Scientific Reports, 2, [266]. https://doi.org/10.1038/srep00266

Vancouver

Levring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A et al. Activated human CD4 T cells express transporters for both cysteine and cystine. Scientific Reports. 2012 Feb 14;2. 266. https://doi.org/10.1038/srep00266

Author

Levring, Trine Bøegh ; Hansen, Ann Kathrine ; Nielsen, Bodil Lisbeth ; Kongsbak, Martin ; von Essen, Marina Rode ; Woetmann, Anders ; Odum, Niels ; Bonefeld, Charlotte Menné ; Geisler, Carsten. / Activated human CD4 T cells express transporters for both cysteine and cystine. In: Scientific Reports. 2012 ; Vol. 2.

Bibtex

@article{e4f5f8b36bdf46e5907d0d67b85abe5b,
title = "Activated human CD4 T cells express transporters for both cysteine and cystine",
abstract = "Because na{\"i}ve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Na{\"i}ve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells.",
author = "Levring, {Trine B{\o}egh} and Hansen, {Ann Kathrine} and Nielsen, {Bodil Lisbeth} and Martin Kongsbak and {von Essen}, {Marina Rode} and Anders Woetmann and Niels Odum and Bonefeld, {Charlotte Menn{\'e}} and Carsten Geisler",
year = "2012",
month = feb,
day = "14",
doi = "10.1038/srep00266",
language = "English",
volume = "2",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Activated human CD4 T cells express transporters for both cysteine and cystine

AU - Levring, Trine Bøegh

AU - Hansen, Ann Kathrine

AU - Nielsen, Bodil Lisbeth

AU - Kongsbak, Martin

AU - von Essen, Marina Rode

AU - Woetmann, Anders

AU - Odum, Niels

AU - Bonefeld, Charlotte Menné

AU - Geisler, Carsten

PY - 2012/2/14

Y1 - 2012/2/14

N2 - Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells.

AB - Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells.

U2 - 10.1038/srep00266

DO - 10.1038/srep00266

M3 - Journal article

C2 - 22355778

VL - 2

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 266

ER -

ID: 38170326