Barrier Immunology

Pærregaard, S.I., Wulff, L., Schussek, S., Niss, K., Mörbe, U., Jendholm, J., Wendland, K., Andrusaite, A.T., Brulois, K.F., Nibbs, R.J.B., Sitnik, K., Mowat, A.M., Butcher, E.C., Brunak, S., Agace, W.W., 2023. The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors. Nat Commun 14, 2307. https://doi.org/10.1038/s41467-023-37952-5

Ahmadi, F., Junghus, F., Ashworth, C., Lappalainen, A., Mörbe, U., Kotarsky, K., Agace, W.W., 2022. cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice. J Exp Med 220, e20221090. https://doi.org/10.1084/jem.20221090

Vergani, S., Muleta, K.G., Silva, C.D., Doyle, A., Kristiansen, T.A., Sodini, S., Krausse, N., Montano, G., Kotarsky, K., Nakawesi, J., Åkerstrand, H., Vanhee, S., Gupta, S.L., Bryder, D., Agace, W.W., Lahl, K., Yuan, J., 2022. A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut. Immunity 55, 1829-1842.e6. https://doi.org/10.1016/j.immuni.2022.08.018

Lança, T., Ungerbäck, J., Silva, C.D., Joeris, T., Ahmadi, F., Vandamme, J., Svensson-Frej, M., Mowat, A.M., Kotarsky, K., Sigvardsson, M., Agace, W.W., 2022. IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage. Immunity 55, 1431-1447.e11. https://doi.org/10.1016/j.immuni.2022.06.006

Luda, K.M., Silva, C.D., Ahmadi, F., Mowat, A.Mcl., Ohno, H., Kotarsky, K., Agace, W.W., 2022. Identification and characterization of murine glycoprotein 2‐expressing intestinal dendritic cells. Scand. J. Immunol. 96, e13219. https://doi.org/10.1111/sji.13219

Jørgensen, P.B., Eriksen, L.L., Fenton, T.M., Bailey, M., Agace, W.W., Mörbe, U.M., 2022. The porcine large intestine contains developmentally distinct submucosal lymphoid clusters and mucosal isolated lymphoid follicles. Dev. Comp. Immunol. 131, 104375. https://doi.org/10.1016/j.dci.2022.104375

Joeris, T., Gomez-Casado, C., Holmkvist, P., Tavernier, S.J., Silva-Sanchez, A., Klotz, L., Randall, T.D., Mowat, A.M., Kotarsky, K., Malissen, B., Agace, W.W., 2021. Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs. Sci Immunol 6. https://doi.org/10.1126/sciimmunol.abd3774

Mörbe, U.M., Jørgensen, P.B., Fenton, T.M., Burg, N. von, Riis, L.B., Spencer, J., Agace, W.W., 2021. Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal Immunol 14, 793–802. https://doi.org/10.1038/s41385-021-00389-4

Jørgensen, P.B., Fenton, T.M., Mörbe, U.M., Riis, L.B., Jakobsen, H.L., Nielsen, O.H., Agace, W.W., 2021. Identification, isolation and analysis of human gut-associated lymphoid tissues. Nat. Protoc. 16, 2051–2067. https://doi.org/10.1038/s41596-020-00482-1

Fenton, T.M., Jørgensen, P.B., Niss, K., Rubin, S.J.S., Mörbe, U.M., Riis, L.B., Silva, C.D., Plumb, A., Vandamme, J., Jakobsen, H.L., Brunak, S., Habtezion, A., Nielsen, O.H., Johansson-Lindbom, B., Agace, W.W., 2020. Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity. Immunity 52, 557-570.e6. https://doi.org/10.1016/j.immuni.2020.02.001

Agace, W.W., McCoy, K.D., 2017. Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape. Immunity 46, 532–548. https://doi.org/10.1016/j.immuni.2017.04.004