Mads Gyrd-Hansen

Mads Gyrd-Hansen

Professor


  1. 2014
  2. Published

    Molecular basis and regulation of OTULIN-LUBAC interaction

    Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, Mads & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2013
  4. Published

    X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

    Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M., Kohl, M. & 10 others, Meerpohl, J. J., Rodeck, B., Kolb, R., Eberl, W., Soerensen, J., von Bernuth, H., Lorenz, M., Schwarz, K., zur Stadt, U. & Ehl, S., 1 Oct 2013, In: Clinical Immunology. 149, 1, p. 133-141 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

    Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

    Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin

    Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, Berthe Katrine, Damgaard, R. B., Gyrd-Hansen, Mads & Hofmann, K., 6 Jun 2013, In: Cell. 153, 6, p. 1312-1326 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2012
  9. Published

    The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

    Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2011
  11. Published

    Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

    Damgaard, R. B. & Gyrd-Hansen, Mads, 2011, In: Discovery Medicine. 11, 58, p. 221-31 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. 2010
  13. Published

    IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer

    Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews Cancer.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  14. Published

    IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

    Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews. Cancer. 10, 8, p. 561-74 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  15. 2008
  16. Published

    Lysosomes and Nonapoptotic Pathways

    Kirkegaard-Sørensen, T., Fehrenbacher, N., Gyrd-Hansen, Mads & Jüüttelü, M., 26 May 2008, Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts. John Wiley and Sons, Inc., Vol. 1. p. 599-622 24 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  17. Published

    IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

    Gyrd-Hansen, Mads, Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C. A., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J. & Meier, P., 2008, In: Nature Cell Biology. 10, 11, p. 1309-17 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2007
  19. Published

    Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

    Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Heregulin-induced epigenetic regulation of the utrophin-A promoter.

    Basu, U., Gyrd-Hansen, Mads, Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, Morten & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2006
  22. Published

    Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9

    Gyrd-Hansen, Mads, Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jaattela, Marja, 2006, In: Molecular and Cellular Biology. 26, 21, p. 7880-7891

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2004
  24. Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.

    Gyrd-Hansen, Mads, Nylandsted, J. & Jäättelä, M., 2004, In: Cell Cycle. 3, 12, p. 1484-5 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.

    Nylandsted, J., Gyrd-Hansen, Mads, Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. & Jäättelä, M., 2004, In: Journal of Experimental Medicine. 200, 4, p. 425-435 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

    Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, Mads, Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, In: Cell Death and Differentiation. 11, 3, p. 301-13 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Sensitization to the lysosomal cell death pathway upon immortalization and transformation.

    Fehrenbacher, N., Gyrd-Hansen, Mads, Poulsen, B., Felbor, U., Kallunki, T., Boes, M., Weber, E., Leist, M. & Jäättelä, M., 2004, In: Cancer Research. 64, 15, p. 5301-10 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2003
  29. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.

    Lademann, U., Cain, K., Gyrd-Hansen, Mads, Brown, D., Peters, D. & Jäättelä, M., 2003, In: Molecular and Cellular Biology. 23, 21, p. 7829-37 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2002
  31. Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.

    Gyrd-Hansen, Mads, Krag, T. O. B., Rosmarin, A. G. & Khurana, T. S., 2002, In: Journal of the Neurological Sciences. 197, 1-2, p. 27-35 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2001
  33. Harnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.

    Krag, T. O., Gyrd-Hansen, Mads & Khurana, T. S., 2001, In: Acta Physiologica (Print Edition). 171, 3, p. 349-58 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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