Vitamin D controls T cell antigen receptor signaling and activation of human T cells

Research output: Contribution to journalJournal articlepeer-review

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Vitamin D controls T cell antigen receptor signaling and activation of human T cells. / von Essen, Marina Rode; Kongsbak-Wismann, Martin; Schjerling, Peter; Ølgaard, Klaus; Ødum, Niels; Geisler, Carsten.

In: Nature Immunology, Vol. 11, No. 4, 2010, p. 344-349.

Research output: Contribution to journalJournal articlepeer-review

Harvard

von Essen, MR, Kongsbak-Wismann, M, Schjerling, P, Ølgaard, K, Ødum, N & Geisler, C 2010, 'Vitamin D controls T cell antigen receptor signaling and activation of human T cells', Nature Immunology, vol. 11, no. 4, pp. 344-349. https://doi.org/10.1038/ni.1851

APA

von Essen, M. R., Kongsbak-Wismann, M., Schjerling, P., Ølgaard, K., Ødum, N., & Geisler, C. (2010). Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nature Immunology, 11(4), 344-349. https://doi.org/10.1038/ni.1851

Vancouver

von Essen MR, Kongsbak-Wismann M, Schjerling P, Ølgaard K, Ødum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nature Immunology. 2010;11(4):344-349. https://doi.org/10.1038/ni.1851

Author

von Essen, Marina Rode ; Kongsbak-Wismann, Martin ; Schjerling, Peter ; Ølgaard, Klaus ; Ødum, Niels ; Geisler, Carsten. / Vitamin D controls T cell antigen receptor signaling and activation of human T cells. In: Nature Immunology. 2010 ; Vol. 11, No. 4. pp. 344-349.

Bibtex

@article{a2d6a5d0723a11df928f000ea68e967b,
title = "Vitamin D controls T cell antigen receptor signaling and activation of human T cells",
abstract = "Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.",
author = "{von Essen}, {Marina Rode} and Martin Kongsbak-Wismann and Peter Schjerling and Klaus {\O}lgaard and Niels {\O}dum and Carsten Geisler",
note = "Keywords: Cells, Cultured; Enzyme Activation; Humans; Immunoblotting; In Situ Hybridization; Lymphocyte Activation; Phospholipase C gamma; Receptors, Antigen, T-Cell; Receptors, Calcitriol; Signal Transduction; Vitamin D",
year = "2010",
doi = "10.1038/ni.1851",
language = "English",
volume = "11",
pages = "344--349",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Vitamin D controls T cell antigen receptor signaling and activation of human T cells

AU - von Essen, Marina Rode

AU - Kongsbak-Wismann, Martin

AU - Schjerling, Peter

AU - Ølgaard, Klaus

AU - Ødum, Niels

AU - Geisler, Carsten

N1 - Keywords: Cells, Cultured; Enzyme Activation; Humans; Immunoblotting; In Situ Hybridization; Lymphocyte Activation; Phospholipase C gamma; Receptors, Antigen, T-Cell; Receptors, Calcitriol; Signal Transduction; Vitamin D

PY - 2010

Y1 - 2010

N2 - Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.

AB - Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.

U2 - 10.1038/ni.1851

DO - 10.1038/ni.1851

M3 - Journal article

C2 - 20208539

VL - 11

SP - 344

EP - 349

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 4

ER -

ID: 20172279