Seminar by Associate Professor Vasileios Bekiaris, DTU

Seminar title: Development and function of IL-17-producing γδ T cells

The LEO Foundation Skin Immunology Research Center is pleased to welcome Associate Professor Vasileios Bekiaris from the Department of Health Technology, DTU.

Interleukin(IL)-17-producing gamma delta T cells (γδT17) are an essential part of innate type 3 immunity against numerous pathogens, while contributing to the pathogenesis of many inflammatory diseases as well as cancer. In the mouse, γδT17 cells undergo multiple developmental checkpoints during embryonic and neonatal life and once mature, they preferentially localize in the dermis and mucosal surfaces such as the gut and lung. With his group, Bekiaris aims to build a network of molecules and pathways that regulate their extra-thymic development, homeostasis and function during inflammation.

In his talk, he will summarize some of the group's data on the JAK/STAT pathway and how it regulates both development and γδT17 cell driven inflammation in the skin and brain. Bekiaris will then present his newest unpublished work on how the E3 ubiquitin ligases cIAP1 and cIAP2 and the non-canonical NF-κB pathway are necessary for functional γδT17 responses in the skin during late neonatal and prepubescent life, and how they sustain this cell population thereafter. 

Time and place: 8 April 2021, 14:30-16:00, https://ucph-ku.zoom.us/j/66045523220